I hold a PhD in Bioengineering from Instituto Superior Técnico - University of Lisbon (IST - ULisbon) and a PhD in Polymers and Biopolymers from Universitat Politècnica de Catalunya (UPC, BarcelonaTech). As a postdoctoral researcher, my research lines include tissue regeneration (skin, cardiac, neural), biosensing and highly controlled drug delivery for cancer treatment and antibacterial applications. Therefore, I work on the synthesis and functionalization of nanoparticles, fibers, films and hydrogels, using advanced manufacturing techniques such as 3D bioprinting, electrospinning, and melt electrowriting of hierarchically organized scaffolds. I have a special focus on multiresponsive (bio)materials, which can respond to varied stimuli: pH, redox, electric, piezoelectric and magnetic.

Within the IMEM group, I am developing multifunctional biomaterials using additive manufacturing techniques, such as 3D cell bioprinting for tissue regeneration and controlled drug delivery for antibacterial applications and cancer treatment. My work is being developed within the project Improving Multifunctional Electro-responsive Bioplatforms by the Optimization of their Core Elements: COmposition, STructure and Attributes (COSTA).

• Resina L*, Perez-Madrigal M, Alemán C. DLP 3D Cell Bioprinting of Gelatin Methacryloyl–Tannic Acid Hydrogels as a Tunable Platform for Bioactive Skin Tissue Engineering Scaffolds. International Journal of Biological Macromolecules 2026, 380, 154131. https://doi.org/10.1016/j.ijbiomac.2026.154131.
• Cancilla F, Palumbo F, Fontana-Escartín A, Alemán C, Resina L*. Multi-responsive anticancer therapeutic membrane based on redox-responsive waterborne polyurethane. Chemical Engineering Journal 2026, 546, 180702. https://doi.org/10.1016/j.cej.2026.180702.
• Cancilla F, Palumbo F, Fiorica C, Pitarressi G, Pérez-Madrigal MM, Alemán C, Resina L*. Multiresponsive Glutathione-Functionalized Waterborne Polyurethane/PEDOT System for Electrically and Redox-Controlled Delivery of an Anticancer Peptide. ACS Applied Polymer Materials 2026, 8, 8479-8494. https://doi.org/10.1021/acsapm.6c00875.
• Viteri A*, Vargas-Estevez C, Colombi S, Resina L, Tan H, Sort J, Ginebra MP, Engel E, Alemán C, García-Torres J*. Three-Dimensional Magnetoelectric Nanocomposite GelMA Hydrogels for Wireless Electrical Stimulation of Cardiac Cells. ACS Applied Materials & Interfaces 2026, 18(19), 28020–28032. https://doi.org/10.1021/acsami.6c05467.
• Castrejón-Comas V, Zanuy D, Fontana-Escartín A, Resina L, Pérez-Madrigal MM*, Alemán C*. Electroresponsive Hydrogel for Wound Healing with Real-Time Monitoring of Bacterial Metabolism to Prevent Infection. ACS Applied Polymer Materials 2026, 8(6), 4117–4130. https://doi.org/10.1021/acsapm.5c04585
• Hidalgo A, Resina L, Casanovas J, Alemán C*, Pérez-Madrigal MM*. Toward Robust Hybrid Nerve Guidance Conduits with Controlled Swelling: A Comparative Evaluation of PLA/PCL Tubes Filled with Polysaccharide Hydrogels. Macromolecular Bioscience 2026, 26(2). https://doi.org/10.1002/mabi.202500613
• Resina L*, Esteves T, Ferreira FC, Alemán C. Recent advances in smart materials for cancer therapy. Journal of Physics D: Applied Physics 2025, 58(46). https://doi.org/10.1088/1361-6463/ae19f4
• Sans J*, Colombi S, Arnau M, Fontana-Escartín A, Resina L, Garcia-Torres J, Alemán C*. Plasma- Assisted and Solvent-Free Ultra-Fast Synthesis of Gold and Gold Oxide Ultra-Small Nanoparticles and its Use as Multi-Sensing Platforms. Small 2025, e06752. https://doi.org/10.1002/smll.202506752
• Haro-Gutiérrez PA, Resina L, Casanovas J, Amoura D, Sánchez M, Pérez-Madrigal MM, Alemán C*. Smart lactate delivery from electro-responsive electrospun fibers. Journal of Drug Delivery Science and Technology 2025, 115 Part 1, 107640. https://doi.org/10.1016/j.jddst.2025.107640
• Resina L*, Caballero P, Guggenbiller G, Weems AC, Pérez-Madrigal MM*, Alemán C*. Multifunctional Scaffold Biosensor and Drug Delivery System for Bacterial Infection Prevention During Skin Wound Healing. Macromolecular Bioscience 2025, e00247. https://doi.org/10.1002/mabi.202500247
• Mohammed-Sadhakathullah AHM, Resina L, Enshaei H, Ivanova K, Tzanov T, Pérez-Madrigal MM, Armelin E, Torras J*. Cholesterol-Functionalized Porous PLA Microparticles for Enhanced Drug Delivery. ACS Applied Bio Materials 2025, 8(9). https://doi.org/10.1021/acsabm.5c00693
• Ramírez-Alba MD, Resina L, Garcia-Torres J, Macovez R, Alemán C*, Pérez-Madrigal MM*. Thiol-yne crosslinked alginate click-hydrogel for the electrical stimulation of skin wound healing. International Journal of Biological
• Macromolecules 2025, 322(Part 3):146880. https://doi.org/10.1016/j.ijbiomac.2025.146880
  Hidalgo A, Resina L, Casanovas J, Enshaei H, Estrany F, Iribarren J, Pérez-Madrigal MM*, Alemán C*. Hydrogel-filled tubular scaffolds for directional tissue regeneration combining shape-memory polyester blends with hyaluronic acid click-hydrogels. RSC Applied Polymers 2025, 3(5):1340-1355. https://doi.org/10.1039/D5LP00098J
• Haro Gutiérrez PA, Colombi S, Casanovas J, Resina L, Sans J, Engel E, Enshaei H, García-Torres J, Pérez-Madrigal MM, Alemán C*. Engineering Poly(lactic Acid)-Based Scaffolds for Abundant, Sustained, and Prolonged Lactate Release. ACS Polymers Au 2025, 5(3). https://doi.org/10.1021/acspolymersau.4c00097
• Castrejón-Comas V, Mataró N, Resina L, Zanuy D, Nuñez-Aulina Q, Sánchez-Moran J, Enshaei H, Arnau M, Muñoz-Galán H, Worch JC, Dove AP, Alemán C*, Pérez-Madrigal MM*. Electro- responsive hyaluronic acid-based click-hydrogels for wound healing. Carbohydrate Polymers 2024, 348, Part B, 122941. https://doi.org/10.1016/j.carbpol.2024.122941
• Molina BG, Enshaei H, Gil A, Haro-Gutierrez PA, Resina L, Sánchez-Jiménez M, Alemán C*. Electroactive self-standing polyester membranes prepared using magnetite/poly(3,4- ethylenedioxythiophene) core-shell particles. Polymer 2024, 311, 127535. https://doi.org/10.1016/j.polymer.2024.127535
• Ramírez-Alba MD, Álvarez-Caballero A, Resina L, Romanini M, Macovez R, Pérez-Madrigal MM*, Alemán C*. Alginate-graft-polyacrylic acid electro-responsive hydrogels: Impact of the conducting polymer and application as hydrogen peroxide sensor. European Polymer Journal 2024, 219, 113388. https://doi.org/10.1016/j.eurpolymj.2024.113388
• Dias D, Resina L, Ferreira FC, Sanjuan-Alberte P*, Esteves T*. Synthesis strategies and cancer therapy applications of PEDOT nanoparticles. Materials Advances 2024, 5(19), 7561-7583. https://doi.org/10.1039/D4MA00260A
• Jones CF, Resina L, Ferreira FC, Sanjuan-Alberte P*, Esteves T*. Conductive Core−Shell Nanoparticles: Synthesis and Applications. The Journal of Physical Chemistry C 2024, 128(27). https://doi.org/10.1021/acs.jpcc.4c02012
• Resina L, Esteves T, Pérez-Rafael S, Hernández-García JI, Ferreira FC, Tzanov T, Bonnard S, Díaz DD, Pérez-Madrigal MM, Alemán C*. Dual electro-/pH-responsive nanoparticle/hydrogel system for controlled delivery of anticancer peptide. Biomaterials Advances 2024, 162, 213925. https://doi.org/10.1016/j.bioadv.2024.213925
• Resina L, Garrudo FFF, Alemán C, Esteves T, Ferreira FC*. Wireless electrostimulation for cancer treatment: an integrated nanoparticle/coaxial fiber mesh platform. Biomaterials Advances 2024, 160, 213830. https://doi.org/10.1016/j.bioadv.2024.213830
• Resina L, Alemán C, Ferreira FC, Esteves T*. (Bio)Molecularly Imprinted Polymers: How Far Have “Plastic Antibodies” Come?. Biotechnology Advances 2023, 68(6), 108220. https://doi.org/10.1016/j.biotechadv.2023.108220
• Frederico B, Garrudo FFF, Alberte P, Resina L, Carvalho M, Jain A, Marques A, Estrany F, Rawson F, Alemán C, Ferreira FC*, Silva JC*. Hydroxyapatite-Filled Osteoinductive and Piezoelectric Nanofibers for Bone Tissue Engineering. Science and Technology of Advanced Materials 2023, 24(1), 2242242. https://doi.org/ 10.1080/14686996.2023.2242242
• Garrudo FFF, Filippone G, Resina L, Silva JC, Barbosa F, Ferreira LFV, Esteves T, Marques AC, Morgado J*, Ferreira FC*. Production of Blended Poly(acrylonitrile): Poly(ethylenedioxythiophene):Poly(styrene sulfonate) Electrospun Fibers for Neural Applications. Polymers 2023, 15(13), 2760. https://doi.org/10.3390/polym15132760
• Resina L, El Hauadi K, Sans J, Esteves T, Ferreira FC, Pérez-Madrigal MM, Alemán C*. Electroresponsive and pH-Sensitive Hydrogel as Carrier for Controlled Chloramphenicol Release. Biomacromolecules 2023, 24, 3, 1432-1444. https://doi.org/10.1021/acs.biomac.2c01442
• Resina L ● , El Hauadi K ● , Zanuy D, Esteves T, Ferreira FC, Pérez-Madrigal MM, Alemán C*. Dendritic Self-assembled Structures from Therapeutic Charged Pentapeptides. Langmuir 2022, 38, 42, 12905-12914. https://doi.org/10.1021/acs.langmuir.2c02010. ● equal contributors